反应详情

2-Amino-4-chloropyridine (2.0 g), 5-hydroxyindole (4.1 g), sodium hydride (60% in oil, 1.25 g) and dimethylsulfoxide (20 ml) were stirred at 160° C. for 9.5 hours. Water was added, extraction was performed with ethyl acetate, and purification was performed by silica gel column chromatography (hexane:ethyl acetate=1:1, ethyl acetate). The solvent was distilled off under reduced pressure, a small amount of ethyl acetate was added to the residue and the solid was filtered out to obtain 490 mg of a light brown solid.

1. extractionextraction
2. customwas performed with ethyl acetate, and purification
3. distillationThe solvent was distilled off under reduced pressure
4. additiona small amount of ethyl acetate was added to the residue
5. filtrationthe solid was filtered out