phenyl N-(1,3-thiazol-2-yl)carbamate → HCID 58931002, compound

HRID 387871Notes

Reaction equation

HRID 387871 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[NH:23][C:10]2[N:11]=[CH:12][N:13]=[C:14]([O:15][C:16]3[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=3)[C:9]=2[CH:8]=1.C1([O:30][C:31](=O)[NH:32][C:33]2[S:34][CH:35]=[CH:36][N:37]=2)C=CC=CC=1>CS(C)=O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[NH:23][C:10]2[N:11]=[CH:12][N:13]=[C:14]([O:15][C:16]3[CH:21]=[CH:20][C:19]([NH:22][C:31]([NH:32][C:33]4[S:34][CH:35]=[CH:36][N:37]=4)=[O:30])=[CH:18][CH:17]=3)[C:9]=2[CH:8]=1

Participants

4

Reactant 2

HCID 651148phenyl N-(1,3-thiazol-2-yl)carbamateHCID 58931472HCID 58931472, compound

Product 1

HCID 58931002HCID 58931002, compoundYield 77.7%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

4-(6-(Pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenylamine (100 mg) and (thiazol-2-yl)carbamic acid phenyl ester (116 mg) were heated and stirred in dimethylsulfoxide (2.5 ml) at 80° C. for 1 hour, in the same manner as Example 224, to obtain the title compound (110 mg) as a solid.

Sources & evidence

ORD record
ord-4ba41eb2daa8448b9813605e14b6caf5
Source dataset
uspto-grants-2013_02
Patent number
US08372981B2

Reaction notes

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