反应详情

After dissolving N-(4-[(7-cyano-6-methoxy-4-quinolyl)oxy]phenyl)-N′-(4-fluorophenyl)urea (43 mg) in 1.5 ml of dimethylsulfoxide at 80° C., a 5N aqueous NaOH solution was added thereto and the mixture was heated and stirred for 2 hours. The reaction solution was neutralized with 1N HCl and the precipitated crystals were filtered out and washed with ethanol to obtain 17 mg of the title compound.

1. temperaturethe mixture was heated
2. filtrationthe precipitated crystals were filtered out
3. washwashed with ethanol