HCID 67202400, compound → Methyl 4-hydroxyfuro[2,3-B]pyridine-2-carboxylate

HRID 387967Notes

Reaction equation

HRID 387967 reaction equation
[CH3:1][O:2][C:3]([C:5]1[O:6][C:7]([NH:10][CH:11]=[C:12]2[C:17](=[O:18])OC(C)(C)OC2=O)=[CH:8][CH:9]=1)=[O:4]>C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[CH3:1][O:2][C:3]([C:5]1[O:6][C:7]2[NH:10][CH:11]=[CH:12][C:17](=[O:18])[C:8]=2[CH:9]=1)=[O:4]

Participants

3

Reactant 1

HCID 67202400HCID 67202400, compound

Product 1

HCID 58931135Methyl 4-hydroxyfuro[2,3-B]pyridine-2-carboxylateYield 76.4%

Reagents, catalysts & solvents 1

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)Solvent

Conditions

Temperature
200 °C

Procedure

After adding 5-[(2,2-dimethyl-4,6-dioxo-[1.3]dioxan-5-ylidenemethyl)amino]furan-2-carboxylic acid methyl ester (4.0 g) to Dowtherm A (30 ml), the mixture was heated and stirred at 200° C. for 1 hour. After cooling, the precipitated crystals were filtered out and washed with diethyl ether to obtain the title compound (2.0 g).

Workup

  1. temperaturethe mixture was heated
  2. temperatureAfter cooling
  3. filtrationthe precipitated crystals were filtered out
  4. washwashed with diethyl ether

Sources & evidence

ORD record
ord-f84f90df17694c9b941f6f8a323e5a1f
Source dataset
uspto-grants-2013_02
Patent number
US08372981B2

Reaction notes

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