Dimethyl Sulfoxide → HCID 86591475, compound

HRID 387976Notes

Reaction equation

HRID 387976 reaction equation
[CH:1]1([NH2:4])[CH2:3][CH2:2]1.CS(C)=O.C1([O:15][C:16](=O)[NH:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][C:25]3[C:34]4[C:29](=[CH:30][C:31]([O:37][CH2:38][C@H:39]5[CH2:41][O:40]5)=[C:32]([C:35]#[N:36])[CH:33]=4)[N:28]=[CH:27][CH:26]=3)=[CH:20][C:19]=2[F:42])C=CC=CC=1.O>C(OCC)(=O)C>[F:42][C:19]1[CH:20]=[C:21]([O:24][C:25]2[C:34]3[C:29](=[CH:30][C:31]([O:37][CH2:38][C@H:39]4[CH2:41][O:40]4)=[C:32]([C:35]#[N:36])[CH:33]=3)[N:28]=[CH:27][CH:26]=2)[CH:22]=[CH:23][C:18]=1[NH:17][C:16]([NH:4][CH:1]1[CH2:3][CH2:2]1)=[O:15]

Participants

6

Reactant 4

HCID 679Dimethyl SulfoxideHCID 962WaterHCID 69828CyclopropylamineHCID 86591476HCID 86591476, compound

Product 1

HCID 86591475HCID 86591475, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Cyclopropylamine (0.04 ml) was added to dimethylsulfoxide (3 ml), and then [2-fluoro-4-([6-cyano-7-([(2R)-oxiran-2-yl]methoxy)-4-quinolyl]oxy)phenyl]carbamic acid phenyl ester (212 mg) was dissolved therein and the solution was stirred for 10 minutes. Water and ethyl acetate were added to the reaction solution, and the precipitated crystals were filtered out to obtain the title compound (150 mg).

Workup

  1. filtrationthe precipitated crystals were filtered out

Sources & evidence

ORD record
ord-02763136eb1b44dd988e5e2632b6b93f
Source dataset
uspto-grants-2013_02
Patent number
US08372981B2

Reaction notes

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