反应详情

温度

85 °C

After adding 400 mg of iron powder, 1 g of ammonium chloride, 20 ml of ethanol, 10 ml of tetrahydrofuran and 10 ml of water to 470 mg of 6-(4-benzyloxyphenyl)-4-(3-fluoro-4-nitrophenoxy)-7-(trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine, the mixture was stirred at 85° C. for 3 hours. After returning it to room temperature, it was filtered with celite, and ethyl acetate and water were added to the filtrate for liquid separation and extraction. The organic layer was washed with saturated saline, dried over anhydrous sodium sulfate, filtered with plug cotton, concentrated and subjected to NH silica gel column chromatography (hexane-ethyl acetate) to obtain 263 mg of the title compound.

1. customto room temperature
2. filtrationit was filtered with celite, and ethyl acetate and water
3. additionwere added to the filtrate for liquid separation and extraction
4. washThe organic layer was washed with saturated saline
5. dry with materialdried over anhydrous sodium sulfate
6. filtrationfiltered with plug cotton
7. concentrationconcentrated