Dimethyl Sulfoxide → HCID 22936456, compound

HRID 388065Notes

Reaction equation

HRID 388065 reaction equation
[CH2:1]([NH2:3])[CH3:2].CS(C)=O.C1([O:14][C:15](=O)[NH:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][C:24]3[C:33]4[C:28](=[CH:29][C:30]([O:37][CH3:38])=[C:31]([C:34](=[O:36])[NH2:35])[CH:32]=4)[N:27]=[CH:26][CH:25]=3)=[CH:19][C:18]=2[C:39]([F:42])([F:41])[F:40])C=CC=CC=1.O>C(OCC)(=O)C>[C:34]([C:31]1[CH:32]=[C:33]2[C:28](=[CH:29][C:30]=1[O:37][CH3:38])[N:27]=[CH:26][CH:25]=[C:24]2[O:23][C:20]1[CH:21]=[CH:22][C:17]([NH:16][C:15]([NH:3][CH2:1][CH3:2])=[O:14])=[C:18]([C:39]([F:41])([F:40])[F:42])[CH:19]=1)(=[O:36])[NH2:35]

Participants

6

Reactant 4

HCID 679Dimethyl SulfoxideHCID 962WaterHCID 6341EthylamineHCID 67202368HCID 67202368, compound

Product 1

HCID 22936456HCID 22936456, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Ethylamine 2N tetrahydrofuran solution (0.10 ml) was added to dimethylsulfoxide (0.5 ml), and then (4-(6-carbamoyl-7-methoxy-4-quinolyl)oxy-2-trifluoromethylphenyl) carbamic acid phenyl ester (25 mg) was dissolved therein and the mixture was stirred for 10 minutes. Water and ethyl acetate were added to the reaction solution, and the precipitated crystals were filtered out to obtain the title compound (5.0 mg).

Workup

  1. filtrationthe precipitated crystals were filtered out

Sources & evidence

ORD record
ord-e63f7b3dcb8e484fbfc0e023fc57caae
Source dataset
uspto-grants-2013_02
Patent number
US08372981B2

Reaction notes

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