Methylamine → HCID 22936664, compound

HRID 388066Notes

Reaction equation

HRID 388066 reaction equation
C1([O:7][C:8](=O)[NH:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][C:17]3[C:26]4[C:21](=[CH:22][C:23]([O:30][CH3:31])=[C:24]([C:27](=[O:29])[NH2:28])[CH:25]=4)[N:20]=[CH:19][CH:18]=3)=[CH:12][C:11]=2[C:32]([F:35])([F:34])[F:33])C=CC=CC=1.[CH3:37][NH2:38]>>[C:27]([C:24]1[CH:25]=[C:26]2[C:21](=[CH:22][C:23]=1[O:30][CH3:31])[N:20]=[CH:19][CH:18]=[C:17]2[O:16][C:13]1[CH:14]=[CH:15][C:10]([NH:9][C:8]([NH:38][CH3:37])=[O:7])=[C:11]([C:32]([F:34])([F:33])[F:35])[CH:12]=1)(=[O:29])[NH2:28]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 67202368HCID 67202368, compound

Product 1

HCID 22936664HCID 22936664, compound

Procedure

After adding [4-(6-carbamoyl-7-methoxy-4-quinolyl)oxy-2-trifluoromethylphenyl]carbamic acid phenyl ester (25 mg) to methylamine 2N tetrahydrofuran solution (1.00 ml), the mixture was stirred for 10 minutes. The precipitated crystals were filtered out and washed with tetrahydrofuran to obtain the title compound (10 mg).

Workup

  1. filtrationThe precipitated crystals were filtered out
  2. washwashed with tetrahydrofuran

Sources & evidence

ORD record
ord-8c6621d21c9c4d98b3c729d0fccb6a60
Source dataset
uspto-grants-2013_02
Patent number
US08372981B2

Reaction notes

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