1,4-Dioxane hydrochloride → HCID 136377315, compound

HRID 388237Notes

Reaction equation

HRID 388237 reaction equation
[O:1]=[C:2]1[C@H:8]([CH2:9][C:10]([O:12][CH2:13][C:14]([N:16]([CH3:18])[CH3:17])=[O:15])=[O:11])[CH2:7][C:6]2[CH:19]=[CH:20][C:21]([O:23][CH2:24][CH2:25][C:26]3[N:27]=[C:28]4[N:33](C(OC(C)(C)C)=O)[CH2:32][CH2:31][CH2:30][N:29]4[CH:41]=3)=[CH:22][C:5]=2[CH2:4][N:3]1[CH2:42][C:43]([F:46])([F:45])[F:44].[ClH:47].O1CCOCC1>ClCCl>[ClH:47].[O:1]=[C:2]1[C@H:8]([CH2:9][C:10]([O:12][CH2:13][C:14]([N:16]([CH3:18])[CH3:17])=[O:15])=[O:11])[CH2:7][C:6]2[CH:19]=[CH:20][C:21]([O:23][CH2:24][CH2:25][C:26]3[N:27]=[C:28]4[NH:33][CH2:32][CH2:31][CH2:30][N:29]4[CH:41]=3)=[CH:22][C:5]=2[CH2:4][N:3]1[CH2:42][C:43]([F:46])([F:45])[F:44]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 66719102HCID 66719102, compound

Product 1

HCID 136377315HCID 136377315, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 4 mL of a dichloromethane solution containing 125 mg (0.192 mmol) of (N,N-dimethylaminocarbonyl)methyl(4S)-3-oxo-8-[2-(8-tert-butoxycarbonyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidin-2-yl)ethoxy]-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepin-4-acetate obtained in Example 12-(a) was added 864 μL (3.46 mmol) of 4N hydrogen chloride/1,4-dioxane solution, and the resulting mixture was stirred under under argon gas atmosphere at room temperature for 19.5 hours.

Sources & evidence

ORD record
ord-d23458dbf4d941d69c691f2a12303cf7
Source dataset
uspto-grants-2013_02
Patent number
US08377922B2

Reaction notes

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