1,4-Dioxane hydrochloride → HCID 136377315, compound

Participants

Reaction Steps

To 4 mL of a dichloromethane solution containing 125 mg (0.192 mmol) of (N,N-dimethylaminocarbonyl)methyl(4S)-3-oxo-8-[2-(8-tert-butoxycarbonyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidin-2-yl)ethoxy]-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepin-4-acetate obtained in Example 12-(a) was added 864 μL (3.46 mmol) of 4N hydrogen chloride/1,4-dioxane solution, and the resulting mixture was stirred under under argon gas atmosphere at room temperature for 19.5 hours.

Provenance & Evidence