1-Methylpiperazine → 1-Methyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine

HRID 388238Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 388238
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12].[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>CO.O>[CH3:15][N:16]1[CH2:21][CH2:20][N:19]([C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=2[C:11]([F:14])([F:13])[F:12])[CH2:18][CH2:17]1

Komponenten

5

Edukt 2

HCID 531671-MethylpiperazineHCID 949542-Fluoro-5-nitrobenzotrifluoride

Produkt 1

HCID 31280181-Methyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

2-Fluoro-5-nitrobenzotrifluoride (2 g) and 1-methylpiperazine (2 mL) were dissolved in methanol (5 mL). The yellow solution was stirred at rt overnight. The reaction mixture was diluted with water (100 mL) and extracted with ethyl acetate (2×100 mL). The organic solutions were evaporated to give 2-(4-methylpiperazino)-5-nitrobenzotrifluoride.

Aufarbeitung

  1. extractionextracted with ethyl acetate (2×100 mL)
  2. customThe organic solutions were evaporated

Quellen und Nachweise

ORD-Eintrag
ord-8e10d5100d4a4836a4774419c19704fe
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08377924B2

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