化工社化工社 化学情報印刷レポート · 研究参考用
Sulfuric Acid → Methyl phenylacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | Benzeneacetic acid, alpha-methyl-, ion(1-) | HCID 5249702 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methyl phenylacetate | HCID 7559 | 95% |
反応手順
To a stirred solution of 2-methyl-2-phenylacetate (10 g, 1 eq) in dry MeOH was added sulfuric acid (1.0 mL) dropwise and heated to reflux. Stirring was then continued for 2 hours. The reaction mixture was then cooled and poured into saturated aqueous NaHCO3 and extracted with EtOAc. The combined organic fractions were dried over Na2SO4, filtered, and concentrated under reduced pressure to yield an oil (10.5 g, 95%) that was not further purified.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08377930B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-40b8e3d60379432495ad1fe6c7b3da00 |
| 出典メモ | uspto-grants-2013_02 |