反应详情

To a stirred solution of 2-methyl-2-phenylacetate (10 g, 1 eq) in dry MeOH was added sulfuric acid (1.0 mL) dropwise and heated to reflux. Stirring was then continued for 2 hours. The reaction mixture was then cooled and poured into saturated aqueous NaHCO3 and extracted with EtOAc. The combined organic fractions were dried over Na2SO4, filtered, and concentrated under reduced pressure to yield an oil (10.5 g, 95%) that was not further purified.

1. temperatureheated to reflux
2. temperatureThe reaction mixture was then cooled
3. extractionextracted with EtOAc
4. dry with materialThe combined organic fractions were dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure