HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-Chloro-4-(3-methanesulfonyl-benzenesulfonyl)-8-piperazin-1-yl-3,4-dihydro-2h-benzo[1,4]oxazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 3-(Methylsulfonyl)benzenesulfonyl chloride | HCID 220330 | — |
| Reactant | 4-(6-Tert-butyl-3,4-dihydro-2h-benzo[1,4]oxazin-8-yl)-piperazine-1-carboxylic acid tert-butyl ester | HCID 69058571 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-Chloro-4-(3-methanesulfonyl-benzenesulfonyl)-8-piperazin-1-yl-3,4-dihydro-2h-benzo[1,4]oxazine | HCID 22557266 | — |
Reaction Steps
Similarly, but replacing 4-(6-chloro-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)-piperazine-1-carboxylic acid tert-butyl ester with 4-(6-tert-butyl-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)-piperazine-1-carboxylic acid tert-butyl ester, and replacing 3-methylsulfonyl-benzenesulfonyl chloride with the appropriate aryl- or heteroaryl-sulfonyl chlorides followed by de-protection using trifluoracetic acid or hot hydrogen chloride in ethanol, the following was prepared:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08377931B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-d89b628ce7d14b839d5120a668f41dd1 |
| Source note | uspto-grants-2013_02 |