Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | N-Methylmethanesulfonamide | HCID 97632 | — |
| Reactant | 2-Fluoro-4-methylbenzonitrile | HCID 2778443 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 58506359 | HCID 58506359 | — |
Reaction Steps
2-fluoro-4-methylbenzonitrile (4.6 g, 34.4 mmol) and N-methyl-methanesulphonamide (7.5 g, 68.7 mmol) are dissolved in 15 mL NMP and stirred for 16 h at 120° C. After the reaction has ended the reaction mixture is mixed with 70 mL water and the solid B-1a (HPLC-MS: tRet.=1.22 min; MS (M+NH4)+=242) is suction filtered and used without any further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08377943B2 |
|---|
| Source dataset | uspto-grants-2013_02 |
|---|
| ORD ID | ord-f74ed7331cee4ad79f1904a76bd5d890 |
|---|
| Source note | uspto-grants-2013_02 |
|---|
