Water → HCID 58506359, compound

HRID 388361Notes

Reaction equation

HRID 388361 reaction equation
F[C:2]1[CH:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[CH3:11][NH:12][S:13]([CH3:16])(=[O:15])=[O:14].O>CN1C(=O)CCC1>[C:4]([C:3]1[CH:6]=[CH:7][C:8]([CH3:10])=[CH:9][C:2]=1[N:12]([CH3:11])[S:13]([CH3:16])(=[O:15])=[O:14])#[N:5]

Participants

5

Reactant 3

HCID 962WaterHCID 97632N-MethylmethanesulfonamideHCID 27784432-Fluoro-4-methylbenzonitrile

Product 1

HCID 58506359HCID 58506359, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
120 °C

Procedure

2-fluoro-4-methylbenzonitrile (4.6 g, 34.4 mmol) and N-methyl-methanesulphonamide (7.5 g, 68.7 mmol) are dissolved in 15 mL NMP and stirred for 16 h at 120° C. After the reaction has ended the reaction mixture is mixed with 70 mL water and the solid B-1a (HPLC-MS: tRet.=1.22 min; MS (M+NH4)+=242) is suction filtered and used without any further purification.

Workup

  1. filtrationthe solid B-1a (HPLC-MS: tRet.=1.22 min; MS (M+NH4)+=242) is suction filtered
  2. customused without any further purification

Sources & evidence

ORD record
ord-f74ed7331cee4ad79f1904a76bd5d890
Source dataset
uspto-grants-2013_02
Patent number
US08377943B2

Reaction notes

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