反应详情

温度

95 °C

Sodium bicarbonate (1.4 g) is added to a solution of crude 1-bromo-4-bromomethyl-naphthalene (2.5 g) in DMSO (25 ml). The reaction is stirred for 3 h at 95° C. and cooled down to room temperature. Water is added and the mixture is extracted with ethyl acetate. The organic phase is dried over MgSO4 and concentrated in vacuo. The crude product is purified on a semi-preparative HPLC to yield 4-bromo-naphthalene-1-carbaldehyde as colorless crystals.

1. temperaturecooled down to room temperature
2. extractionthe mixture is extracted with ethyl acetate
3. dry with materialThe organic phase is dried over MgSO4
4. concentrationconcentrated in vacuo
5. customThe crude product is purified on a semi-preparative HPLC