Hydrochloric Acid → 6-(trifluoromethyl)pyridazine-3-carboxylic acid

Participants

Reaction Steps

A solution of ethyl 6-(trifluoromethyl)-3-pyridazinecarboxylate (73 mg, 0.332 mmol) in ethanol (1 ml) was treated with 2M sodium hydroxide (2 ml, 4.00 mmol) and stirred overnight at room temperature. The suspension was then acidified by addition of dilute hydrochloric acid and extracted twice with ethyl acetate. The combined extracts were dried over MgSO4 and evaporated under reduced pressure to afford the title compound as a pale solid (60 mg);

Provenance & Evidence