Hydrochloric Acid → 6-(trifluoromethyl)pyridazine-3-carboxylic acid

HRID 388385Notes

Reaction equation

HRID 388385 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[N:8]=[N:7][C:6]([C:9]([O:11]CC)=[O:10])=[CH:5][CH:4]=1.[OH-].[Na+].Cl>C(O)C>[F:15][C:2]([F:1])([F:14])[C:3]1[N:8]=[N:7][C:6]([C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 52987966Ethyl 6-(trifluoromethyl)pyridazine-3-carboxylate

Product 1

HCID 581268206-(trifluoromethyl)pyridazine-3-carboxylic acidYield 94.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of ethyl 6-(trifluoromethyl)-3-pyridazinecarboxylate (73 mg, 0.332 mmol) in ethanol (1 ml) was treated with 2M sodium hydroxide (2 ml, 4.00 mmol) and stirred overnight at room temperature. The suspension was then acidified by addition of dilute hydrochloric acid and extracted twice with ethyl acetate. The combined extracts were dried over MgSO4 and evaporated under reduced pressure to afford the title compound as a pale solid (60 mg);

Workup

  1. extractionextracted twice with ethyl acetate
  2. dry with materialThe combined extracts were dried over MgSO4
  3. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-e784d711c9f34e45b8803a7c486994c2
Source dataset
uspto-grants-2013_02
Patent number
US08377941B2

Reaction notes

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