Hydrochloric Acid → HCID 9350311, compound

HRID 388406Notes

Reaction equation

HRID 388406 reaction equation
[CH3:1][C:2]1[C:10]2[C:9](=[O:11])[NH:8][C:7]([CH2:12][N:13]3[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]3)=[N:6][C:5]=2[S:4][C:3]=1[C:19]([O:21]CC)=[O:20].Cl>[OH-].[Na+]>[CH3:1][C:2]1[C:10]2[C:9](=[O:11])[NH:8][C:7]([CH2:12][N:13]3[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]3)=[N:6][C:5]=2[S:4][C:3]=1[C:19]([OH:21])=[O:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 3301642HCID 3301642, compound

Product 1

HCID 9350311HCID 9350311, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
80 °C

Procedure

671 Milligrams of ethyl 5-methyl-4-oxo-2-piperidinomethyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate was suspended in 8 mL of 0.5N sodium hydroxide, stirred at 80° C. for 2 hours, and allowed to cool off. The reaction liquid was neutralized with 2N hydrochloric acid, and the precipitate was recovered by filtration and dried, to provide 565 mg (92%) of the title compound.

Workup

  1. temperatureto cool off
  2. customThe reaction liquid
  3. filtrationthe precipitate was recovered by filtration
  4. customdried

Sources & evidence

ORD record
ord-2a10179eb93f454da88ccdff1c61b948
Source dataset
uspto-grants-2013_02
Patent number
US08377944B2

Reaction notes

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