Hydrochloric Acid → HCID 57821247, compound

HRID 388408Notes

Reaction equation

HRID 388408 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[NH:16][C:17](=[O:30])[C:18]3[C:23]([CH3:24])=[C:22]([C:25]([O:27]CC)=[O:26])[S:21][C:19]=3[N:20]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl>[OH-].[Na+]>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([CH2:14][C:15]2[NH:16][C:17](=[O:30])[C:18]3[C:23]([CH3:24])=[C:22]([C:25]([OH:27])=[O:26])[S:21][C:19]=3[N:20]=2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69070807HCID 69070807, compound

Product 1

HCID 57821247HCID 57821247, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
100 °C

Procedure

436 Milligrams of ethyl 2-(4-tert-butoxycarbonylpiperazin-1-ylmethyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate as synthesized in Production Example 21 was suspended in 4 mL of 0.5N sodium hydroxide and stirred at 100° C. for 2 hours. After cooling off, the reaction liquid was neutralized with 1N hydrochloric acid, and the precipitate was recovered by filtration. Drying the same, 377 mg (92%) of the title compound was obtained.

Workup

  1. temperatureAfter cooling off
  2. customthe reaction liquid
  3. filtrationthe precipitate was recovered by filtration
  4. dry with materialDrying the same, 377 mg (92%) of the title compound
  5. customwas obtained

Sources & evidence

ORD record
ord-d36abb67945d42f899c4f00cdbbc28a8
Source dataset
uspto-grants-2013_02
Patent number
US08377944B2

Reaction notes

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