Hydrochloric Acid → HCID 57821240, compound

HRID 388412Notes

Reaction equation

HRID 388412 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][C:27]=1[Cl:28])[CH2:5][C:6]1[NH:7][C:8](=[O:24])[C:9]2[C:14]([CH3:15])=[C:13]([CH2:16][C:17]([O:19]CCCC)=[O:18])[S:12][C:10]=2[N:11]=1.[OH-].[Na+].Cl>O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][C:27]=1[Cl:28])[CH2:5][C:6]1[NH:7][C:8](=[O:24])[C:9]2[C:14]([CH3:15])=[C:13]([CH2:16][C:17]([OH:19])=[O:18])[S:12][C:10]=2[N:11]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69077483HCID 69077483, compound

Product 1

HCID 57821240HCID 57821240, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
70 °C

Procedure

92 Milligrams of butyl 2-(3,4-dichlorobenzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-acetate as synthesized in Production Example 25 was suspended in 1 mL of water and to which 0.63 mL of 1N aqueous sodium hydroxide solution was added, followed by an hour's stirring at about 70° C. Then the reaction mixture was neutralized with 0.63 mL of 1N hydrochloric acid, and the resulting precipitate was recovered by filtration and dried to provide 87 mg (quantitative) of the title compound.

Workup

  1. additionwas added
  2. waitfollowed by an hour
  3. filtrationthe resulting precipitate was recovered by filtration
  4. customdried

Sources & evidence

ORD record
ord-ba2e44b78d0f4d6995b4e88b745f4413
Source dataset
uspto-grants-2013_02
Patent number
US08377944B2

Reaction notes

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