反应详情

A solution of 4.4 g of 5 and 2.8 g of NaOH in 20 ml of water is kept at reflux for 2.5 h. The reaction mixture is cooled, diluted with water (150 ml) and acidified with conc. HCl (aq). A precipitate forms. The water layer is extracted with EtOAc (2×200 ml; the precipitate slowly dissolves). The combined organic layers are washed with brine and dried (Na2SO4). Concentration afforded 3.9 grams of 6 as a white solid.

1. temperatureat reflux for 2.5 h
2. temperatureThe reaction mixture is cooled
3. extractionThe water layer is extracted with EtOAc (2×200 ml
4. dissolutionthe precipitate slowly dissolves)
5. washThe combined organic layers are washed with brine
6. dry with materialdried (Na2SO4)
7. concentrationConcentration