Trifluoroacetic acid → 6-Oxa-9-azaspiro(4.5)decane

HRID 38842Notes

Reaction equation

HRID 38842 reaction equation
[CH2:1]1[C:5]2([CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7][O:6]2)[CH2:4][CH2:3][CH2:2]1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:4]1[C:5]2([CH2:10][NH:9][CH2:8][CH2:7][O:6]2)[CH2:1][CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 15143399-Boc-6-oxa-9-azaspiro[4.5]decane

Product 1

HCID 224171726-Oxa-9-azaspiro(4.5)decaneYield 173.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a of solution 1,1-dimethylethyl 6-oxa-9-azaspiro[4.5]decane-9-carboxylate (200 mg, 0.829 mmol, available from Tyger Scientific Inc) in DCM (3 ml) was added trifluoroacetic acid (TFA) (0.5 ml). The resulting colourless yellow solution was stirred at room temperature for 24 hr. The solvent was evaporated to give the title compound as a grey oil (203 mg).

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-a356f63a3fe44678bc8ca45e60b4ef6d
Source dataset
uspto-grants-2013_09
Patent number
US08524751B2

Reaction notes

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