HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-cyclohexyl-(2-nitro-benzoylamino)-acetic acid methyl ester → (R)-(2-amino-benzoylamino)-cyclohexyl-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-cyclohexyl-(2-nitro-benzoylamino)-acetic acid methyl ester | HCID 68726619 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (R)-(2-amino-benzoylamino)-cyclohexyl-acetic acid methyl ester | HCID 68728963 | 102.8% |
Reaction Steps
A mixture of (R)-cyclohexyl-(2-nitro-benzoylamino)-acetic acid methyl ester (1.16 g, 3.62 mmol), 10% Pd/C (250 mg) in EtOH (25 mL) are stirred under H2 atmosphere at room temperature for 16 hours. The reaction mixture is filtered and the organic layer is concentrated to give (R)-(2-amino-benzoylamino)-cyclohexyl-acetic acid methyl ester (1.08 g, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08377949B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-45c0417be1c5470b8374183af5f8dde1 |
| Source note | uspto-grants-2013_02 |