反应详情

To a solution of (S)-(4-Chloro-phenyl)-[1-(4,6-dimethyl-1,2-benzisothiazol-3-ylmethyl)-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl]-acetic acid ethyl ester (50 mg, 0.094 mmol) in 1,4-dioxane (10 mL) and water (1 mL) is added LiOH (6.7 mg, 0.28 mmol) at room temperature. The solution is stirred at the same temperature for 4 hours. The solution is concentrated and water is added to the residue. The solution is acidified by 12N HCl in an ice-bath. The precipitated solid is collected by filtration to afford the title compound.: LCMS (ESMS): m/z 506.10 (M+H+)

1. concentrationThe solution is concentrated
2. additionwater is added to the residue
3. customThe solution is acidified by 12N HCl in an ice-bath
4. filtrationThe precipitated solid is collected by filtration