反应详情

温度

60 °C

To a solution of (R)-2-[2,4-dioxo-1-(1,4,6-trimethyl-1H-indol-3-ylmethyl)-1,4-dihydro-2H-quinazolin-3-yl]-pentanoic acid methyl ester (50 mg, 0.11 mmol) in 1,4-dioxane (10 mL) and water (2 mL) is added LiOH (5.4 mg, 0.22 mmol) at room temperature. The solution is stirred at 60° C. for 4 hours. The solution is concentrated and water is added to the residue. The solution is acidified by 12N HCl in an ice-bath. The precipitated white solid is collected by filtration and is dried under vacuum to afford the title product. : LCMS (ESMS): m/z 434.89 (M+H+).

1. concentrationThe solution is concentrated
2. additionwater is added to the residue
3. customThe solution is acidified by 12N HCl in an ice-bath
4. filtrationThe precipitated white solid is collected by filtration
5. customis dried under vacuum