Hydrochloric Acid → HCID 131730212, compound

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Reaction Steps

After suspending N-(2-fluoro-4-{[2-({[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide (63.4 mg) in acetone (0.634 ml), 5N hydrochloric acid (0.020 ml) and water (0.0117 ml) were added at room temperature to form a solution. The solution was stirred overnight at room temperature. The precipitate was collected by filtration and washed with acetone (0.317 ml, 2 times). It was then dried under aeration at room temperature for 30 minutes, and then dried with warm air at 60° C. for 1 day to give the title compound (43.3 mg) as white powder.

Provenance & Evidence