Hydrochloric Acid → HCID 131730212, compound

HRID 388506Notes

Reaction equation

HRID 388506 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]([N:18]3[CH2:23][CH2:22][CH:21]([N:24]4[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]4)[CH2:20][CH2:19]3)=[O:17])[CH:10]=2)[CH:5]=[CH:4][C:3]=1[NH:31][C:32]([CH2:34][C:35]1([CH2:38][C:39]([NH:41][C:42]2[CH:47]=[CH:46][C:45]([F:48])=[CH:44][CH:43]=2)=[O:40])[CH2:37][CH2:36]1)=[O:33].[ClH:49]>CC(C)=O.O>[ClH:49].[F:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]([N:18]3[CH2:19][CH2:20][CH:21]([N:24]4[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]4)[CH2:22][CH2:23]3)=[O:17])[CH:10]=2)[CH:5]=[CH:4][C:3]=1[NH:31][C:32]([CH2:34][C:35]1([CH2:38][C:39]([NH:41][C:42]2[CH:47]=[CH:46][C:45]([F:48])=[CH:44][CH:43]=2)=[O:40])[CH2:37][CH2:36]1)=[O:33]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 131730213HCID 131730213, compound

Product 1

HCID 131730212HCID 131730212, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

After suspending N-(2-fluoro-4-{[2-({[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide (63.4 mg) in acetone (0.634 ml), 5N hydrochloric acid (0.020 ml) and water (0.0117 ml) were added at room temperature to form a solution. The solution was stirred overnight at room temperature. The precipitate was collected by filtration and washed with acetone (0.317 ml, 2 times). It was then dried under aeration at room temperature for 30 minutes, and then dried with warm air at 60° C. for 1 day to give the title compound (43.3 mg) as white powder.

Workup

  1. additionwere added at room temperature
  2. customto form a solution
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with acetone (0.317 ml, 2 times)
  5. customIt was then dried under aeration at room temperature for 30 minutes
  6. customdried
  7. temperaturewith warm air at 60° C. for 1 day

Sources & evidence

ORD record
ord-afccd0be46bd40b0b86dceed0a32750a
Source dataset
uspto-grants-2013_02
Patent number
US08377938B2

Reaction notes

Loading…