Hydrogen Bromide → HCID 131730214, compound

Participants

Reaction Steps

After suspending N-(2-fluoro-4-{[2-({[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide (55.7 mg) in water (1.67 ml), 48% aqueous hydrobromic acid (0.010 ml) was added at room temperature to form an aqueous solution. A dry ice/ethanol bath was used to freeze the aqueous solution, after which it was lyophilized under reduced pressure for 27 hours to give the title compound (70.7 mg) as white powder.

Provenance & Evidence