Hydrogen Bromide → HCID 131730214, compound

HRID 388507Notes

Reaction equation

HRID 388507 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]([N:18]3[CH2:23][CH2:22][CH:21]([N:24]4[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]4)[CH2:20][CH2:19]3)=[O:17])[CH:10]=2)[CH:5]=[CH:4][C:3]=1[NH:31][C:32]([CH2:34][C:35]1([CH2:38][C:39]([NH:41][C:42]2[CH:47]=[CH:46][C:45]([F:48])=[CH:44][CH:43]=2)=[O:40])[CH2:37][CH2:36]1)=[O:33].[BrH:49]>O>[BrH:49].[F:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]([N:18]3[CH2:19][CH2:20][CH:21]([N:24]4[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]4)[CH2:22][CH2:23]3)=[O:17])[CH:10]=2)[CH:5]=[CH:4][C:3]=1[NH:31][C:32]([CH2:34][C:35]1([CH2:38][C:39]([NH:41][C:42]2[CH:47]=[CH:46][C:45]([F:48])=[CH:44][CH:43]=2)=[O:40])[CH2:37][CH2:36]1)=[O:33]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 131730213HCID 131730213, compound

Product 1

HCID 131730214HCID 131730214, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

After suspending N-(2-fluoro-4-{[2-({[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide (55.7 mg) in water (1.67 ml), 48% aqueous hydrobromic acid (0.010 ml) was added at room temperature to form an aqueous solution. A dry ice/ethanol bath was used to freeze the aqueous solution, after which it was lyophilized under reduced pressure for 27 hours to give the title compound (70.7 mg) as white powder.

Workup

  1. additionwas added at room temperature
  2. customto form an aqueous solution
  3. customA dry ice/ethanol bath was used

Sources & evidence

ORD record
ord-4802fb77fb7a451994a7a87bcc90f5e2
Source dataset
uspto-grants-2013_02
Patent number
US08377938B2

Reaction notes

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