反应详情

温度

70 °C

Concentrated hydrochloric acid (46.9 ml, 1543 mmol) was added to a stirred suspension of 6-bromo-1H-indazole-4-carboxylic acid (4.65 g, 19.29 mmol, available from Sinova) in methanol (100 ml) and the reaction mixture was heated to 70° C. for 18 h. The reaction mixture was allowed to cool to RT resulting in the precipitation of a solid. The mixture was cooled in ice and the yellow precipitate filtered off and washed with methanol to give the title compound as a yellow solid (2.54 g).

1. temperatureto cool to RT
2. customresulting in the precipitation of a solid
3. temperatureThe mixture was cooled in ice
4. filtrationthe yellow precipitate filtered off
5. washwashed with methanol