Succinic Acid → HCID 131730217, compound

HRID 388510Notes

Reaction equation

HRID 388510 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]([N:18]3[CH2:23][CH2:22][CH:21]([N:24]4[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]4)[CH2:20][CH2:19]3)=[O:17])[CH:10]=2)[CH:5]=[CH:4][C:3]=1[NH:31][C:32]([CH2:34][C:35]1([CH2:38][C:39]([NH:41][C:42]2[CH:47]=[CH:46][C:45]([F:48])=[CH:44][CH:43]=2)=[O:40])[CH2:37][CH2:36]1)=[O:33].[C:49]([OH:56])(=[O:55])[CH2:50][CH2:51][C:52]([OH:54])=[O:53]>C(O)C>[C:49]([OH:56])(=[O:55])[CH2:50][CH2:51][C:52]([OH:54])=[O:53].[F:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]([N:18]3[CH2:19][CH2:20][CH:21]([N:24]4[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]4)[CH2:22][CH2:23]3)=[O:17])[CH:10]=2)[CH:5]=[CH:4][C:3]=1[NH:31][C:32]([CH2:34][C:35]1([CH2:38][C:39]([NH:41][C:42]2[CH:47]=[CH:46][C:45]([F:48])=[CH:44][CH:43]=2)=[O:40])[CH2:37][CH2:36]1)=[O:33]

Participants

4

Reactant 2

HCID 1110Succinic AcidHCID 131730213HCID 131730213, compound

Product 1

HCID 131730217HCID 131730217, compoundYield 32.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

After suspending N-(2-fluoro-4-{[2-({[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide (31.7 mg) in ethanol (0.317 ml), succinic acid (5.7 mg) was added at room temperature and the mixture was stirred at room temperature for 3 days. The precipitate was collected by filtration and washed with ethanol (0.158 ml). It was then dried under aeration at room temperature for 30 minutes and further dried with warm air at 60° C. for 4 hours to give the title compound (12.0 mg, 32%) as white powder.

Workup

  1. additionwas added at room temperature
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with ethanol (0.158 ml)
  4. customIt was then dried under aeration at room temperature for 30 minutes
  5. customfurther dried
  6. temperaturewith warm air at 60° C. for 4 hours

Sources & evidence

ORD record
ord-7a64fa0744134f2c95cce68e2512772a
Source dataset
uspto-grants-2013_02
Patent number
US08377938B2

Reaction notes

Loading…