Succinic Acid → HCID 131730217, compound

Participants

Reaction Steps

After suspending N-(2-fluoro-4-{[2-({[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide (31.7 mg) in ethanol (0.317 ml), succinic acid (5.7 mg) was added at room temperature and the mixture was stirred at room temperature for 3 days. The precipitate was collected by filtration and washed with ethanol (0.158 ml). It was then dried under aeration at room temperature for 30 minutes and further dried with warm air at 60° C. for 4 hours to give the title compound (12.0 mg, 32%) as white powder.

Provenance & Evidence