Quinoline → HCID 66938066, compound

HRID 388629Notes

Reaction equation

[Br:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[I:9][C:10]1[CH:19]=[CH:18]C2C(=CC=CC=2)N=1.N1C2C(=CC=CC=2)C=CC=1>>[Br:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:3]=1[N:4]=[CH:18][CH:19]=[C:10]2[I:9]

Participants

Reactant 3

HCID 7047Quinoline

HCID 119922-Bromoaniline

HCID 810442-Iodoquinoline

Product 1

HCID 66938066HCID 66938066, compound

Procedure

8-bromo-4-iodoquinoline 43a is synthesized from 2-bromoaniline using the same protocols as those described for the preparation of iodoquinoline fragment 1i in Example 1.

Sources & evidence

ORD record: ord-c74283cc24c54a6fa478e5da816b5a20
Source dataset: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08377960B2

Reaction notes

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