N-(2-acetyl-5-methoxyphenyl)-4-Isopropyl-2-Thiazolecarboxamide → n-(6-Acetyl-3-chloro-4-methoxyphenyl)-4-isopropylthiazole-2-carboxamide

HRID 388664Notes

Reaction equation

HRID 388664 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([O:9][CH3:10])=[CH:4][C:3]=1[C:11](=[O:13])[CH3:12].[CH:14]([C:17]1[N:18]=[C:19]([C:22](Cl)=[O:23])[S:20][CH:21]=1)([CH3:16])[CH3:15].C(C1C=CC(OC)=CC=1NC(C1SC=C(C(C)C)N=1)=O)(=O)C>>[C:11]([C:3]1[C:2]([NH:1][C:22]([C:19]2[S:20][CH:21]=[C:17]([CH:14]([CH3:16])[CH3:15])[N:18]=2)=[O:23])=[CH:7][C:6]([Cl:8])=[C:5]([O:9][CH3:10])[CH:4]=1)(=[O:13])[CH3:12]

Participants

4

Reactant 3

HCID 20773655N-(2-acetyl-5-methoxyphenyl)-4-Isopropyl-2-ThiazolecarboxamideHCID 575787964-(Propan-2-yl)-1,3-thiazole-2-carbonyl chlorideHCID 666504821-(2-Amino-4-chloro-5-methoxyphenyl)ethanone

Product 1

HCID 66650598n-(6-Acetyl-3-chloro-4-methoxyphenyl)-4-isopropylthiazole-2-carboxamideYield 69%

Procedure

N-(6-Acetyl-3-chloro-4-methoxyphenyl)-4-isopropylthiazole-2-carboxamide 217g was synthesized from compounds 201g and 214 as a beige solid in 69% yield, according to the procedure as described for compound 217a. MS (ESI, EI+): m/z=354 (MH+).

Sources & evidence

ORD record
ord-911cc55696054611aa92c085c1a0ef8f
Source dataset
uspto-grants-2013_02
Patent number
US08377962B2

Reaction notes

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