Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4,8-dichloro-7-methoxy-2-(3-(trifluoromethyl)-1H-pyrazol-1-yl)quinoline | HCID 56605213 | — |
| Reactant | HCID 178476685 | HCID 178476685 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 178487711 | HCID 178487711 | 80% |
Reaction Steps
To a solution of compound 235a (250 mg) in DMSO (2.5 mL) was added CH3COOK (3 eq.), water (2 eq.). The reaction mixture was heated to 140° C. for 4 hrs. After cooled to RT, water (1 mL) was added to the reaction mixture slowly under stirring. Solid was filtered and washed with water to yield compound 236a in >80% yield. In a separate reaction, when 5 eq. of CH3COOK was used, the reaction was completed in 1 hr.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08377962B2 |
|---|
| Source dataset | uspto-grants-2013_02 |
|---|
| ORD ID | ord-19ef380d819c499bad56339175ed8fc8 |
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| Source note | uspto-grants-2013_02 |
|---|
