4-Chlorophenylboronic acid → HCID 58282664, compound

HRID 388717Notes

Reaction equation

HRID 388717 reaction equation
Cl[C:2]1[N:7]=[C:6]([N:8]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[N:9]2)[N:5]=[C:4]([O:17][CH3:18])[CH:3]=1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1.COC1C=C(C2C=CC=CC=2)N=C(N2C=CC(C(F)(F)F)=N2)N=1>>[CH3:18][O:17][C:4]1[CH:3]=[C:2]([C:23]2[CH:24]=[CH:25][C:20]([Cl:19])=[CH:21][CH:22]=2)[N:7]=[C:6]([N:8]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[N:9]2)[N:5]=1

Participants

4

Reactant 3

HCID 742994-Chlorophenylboronic acidHCID 58282711HCID 58282711, compoundHCID 59533408HCID 59533408, compound

Product 1

HCID 58282664HCID 58282664, compoundYield 45%

Procedure

4-Methoxy-6-(4-chloro-phenyl)-2-(3-trifluoromethyl-pyrazol-1-yl)-pyrimidine 307e was synthesized from compound 305 (1 g, 3.59 mmol) and (4-chloro-phenyl)-boronic acid 306e (842 mg, 5.39 mmol), according to the procedure as described for compound 307b, was a beige solid in 45% yield. MS (ESI, EI+) m/z=355 (MH+).

Sources & evidence

ORD record
ord-658120dd4c8c410398fe1b634b177a12
Source dataset
uspto-grants-2013_02
Patent number
US08377962B2

Reaction notes

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