反应详情

To a mixture of chloromethyl chlorosulfate (1.1 equivalent) and 4-tert-Butoxycarbonylamino-butyric acid (1 equivalent) was added NaHCO3 (3.6 equivalents) and Bu4NHSO4 (catalytic amount) in water/CH2Cl2 (1:1). The mixture was stirred at room temperature overnight. The organic phase was thereafter separated and the aqueous phase was extracted with CH2Cl2 (three times). The combined organic layer was washed with NaHCO3 (×3), brine (×3), dried with MgSO4, filtered and evaporated.

1. customThe organic phase was thereafter separated
2. extractionthe aqueous phase was extracted with CH2Cl2 (three times)
3. washThe combined organic layer was washed with NaHCO3 (×3), brine (×3)
4. dry with materialdried with MgSO4
5. filtrationfiltered
6. customevaporated