反应详情

4-Amino-1-(naphth-2-ylmethyl)piperidine (1.0 g, 0.0042 m) and benzoylisothiocyanate (0.69 g, 0.0042 m) in toluene (120 cm3) was stirred at room temperature for 6 hours. The solvent was evaporated and the gum dissolved in isopropyl alcohol and acidified with ethanolic HCl. The solvent was evaporated and the residue dissolved in ethyl acetate. The title compound crystallised and was filtered and dried as the monohydrochloride quarterhydrate salt, m.p. 212°-214° C.

1. customThe solvent was evaporated
2. dissolutionthe gum dissolved in isopropyl alcohol
3. customThe solvent was evaporated
4. dissolutionthe residue dissolved in ethyl acetate
5. customThe title compound crystallised
6. filtrationwas filtered
7. dry with materialdried as the monohydrochloride quarterhydrate salt, m.p. 212°-214° C.