反应详情

温度

80 °C

To a solution of 2-fluoro-4-nitrobenzonitrile (10 mmol) in isopropanol (30 mL) was added aqueous hydrazine (4 mL). The resulting solution was heated at 80° C. for 12 h. The reaction mixture was then concentrated, water (30 mL) was added, and the solution was extracted with ethyl acetate (2×25 mL). The combined organics were washed with water (30 mL) and brine (30 mL) and dried over anhydrous sodium sulfate. The volatiles were removed in vacuo yielding 3-amino-6-nitroindazole as an orange solid, which was utilized for further transformation without further purification.

1. concentrationThe reaction mixture was then concentrated
2. additionwater (30 mL) was added
3. extractionthe solution was extracted with ethyl acetate (2×25 mL)
4. washThe combined organics were washed with water (30 mL) and brine (30 mL)
5. dry with materialdried over anhydrous sodium sulfate
6. customThe volatiles were removed in vacuo