反应详情

温度

120 °C

A mixture of [7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate (0.4 g, 0.90 mmol), propan-1-amine (1 ml) and ACN (3 ml) was heated under microwave radiation at 120° C. for 30 min. Purification on SCX-3 column (TEA/MeOH) and on a small silica plug (DCM/MeOH). Yield: 0.2 g, 90%. The amine was converted to the hydrochloric acid salt and crystallized from MeOH/Et2O. M.p. 223° C. MS m/z (rel. intensity, 70 eV) 285 (M+, 5), 256 (4), 207 (5), 73 (5), 72 (bp).

1. customPurification on SCX-3 column (TEA/MeOH)
2. customcrystallized from MeOH/Et2O