Hydrochloric Acid → HCID 178521788, compound

HRID 388963Notes

Reaction equation

HRID 388963 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:33]([C:34](=[O:45])[NH:35][C:36]3[CH:44]=[CH:43][C:39]4[N:40]=[CH:41][S:42][C:38]=4[CH:37]=3)=[CH:32][C:17]3[N:18]=[C:19]([NH:21][C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=4[C:28]([F:31])([F:30])[F:29])[NH:20][C:16]=3[CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[S:42]1[C:38]2[CH:37]=[C:36]([NH:35][C:34]([C:33]3[C:14]([N:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)=[CH:15][C:16]4[NH:20][C:19]([NH:21][C:22]5[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=5[C:28]([F:29])([F:30])[F:31])=[N:18][C:17]=4[CH:32]=3)=[O:45])[CH:44]=[CH:43][C:39]=2[N:40]=[CH:41]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178452215HCID 178452215, compound

Product 1

HCID 178521788HCID 178521788, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product from Example 163 was treated with 4M HCl in dioxane employing the procedure described for Example 156 to afford 6-piperazin-1-yl-2-(2-trifluoromethylphenylamino)-1H-benzoimidazole-5-carboxylic acid benzothiazol-6-ylamide as a hydrochloride salt. MS: m/z 538 (M+H)+.

Sources & evidence

ORD record
ord-200593e42f8347f09ebd1ef8be3ed2c2
Source dataset
uspto-grants-2013_02
Patent number
US08377983B2

Reaction notes

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