Hydrochloric Acid → HCID 178521768, compound

HRID 388971Notes

Reaction equation

HRID 388971 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:30]([C:31](=[O:42])[NH:32][C:33]3[CH:41]=[C:40]4[C:36]([CH:37]=[N:38][NH:39]4)=[CH:35][CH:34]=3)=[CH:29][C:17]3[N:18]=[C:19]([NH:21][C@H:22]4[CH2:27][C@H:26]5[CH2:28][C@@H:23]4[CH2:24][CH2:25]5)[NH:20][C:16]=3[CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[NH:39]1[C:40]2[C:36](=[CH:35][CH:34]=[C:33]([NH:32][C:31]([C:30]3[C:14]([N:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)=[CH:15][C:16]4[NH:20][C:19]([NH:21][C@H:22]5[CH2:27][C@H:26]6[CH2:28][C@@H:23]5[CH2:24][CH2:25]6)=[N:18][C:17]=4[CH:29]=3)=[O:42])[CH:41]=2)[CH:37]=[N:38]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178452217HCID 178452217, compound

Product 1

HCID 178521768HCID 178521768, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product from Example 169 was treated with 4M HCl in dioxane employing the procedure described for Example 156 to afford 2-((1S,2S,4R)-bicyclo[2.2.1]hept-2-ylamino)-6-piperazin-1-yl-1H-benzoimidazole-5-carboxylic acid (1H-indazol-6-yl)amide as a hydrochloride salt. MS: m/z 471 (M+H)+.

Sources & evidence

ORD record
ord-5669a4c625ef45c48da57a6a6de252ae
Source dataset
uspto-grants-2013_02
Patent number
US08377983B2

Reaction notes

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