反应详情

Pyrrolidone hydrotribromide (1.8 g, 3.6 mmol) was added to a solution of 1-(1H-indazol-6-yl)ethanone (0.5 g, 3 mmol) in THF (10 mL) and the solution was heated at reflux for 2 h. The solution was allowed to cool to room temperature and H2O (30 mL) was added and the mixture was extracted with EtOAc (3×20 mL) and dried (MgSO4). The solvent was removed at reduced pressure to afford 2-bromo-1-(1H-indazol-6-yl)-ethanone, which was used directly in the next step with no purification.

1. temperaturethe solution was heated
2. temperatureat reflux for 2 h
3. extractionthe mixture was extracted with EtOAc (3×20 mL)
4. dry with materialdried (MgSO4)
5. customThe solvent was removed at reduced pressure