Ammonium Chloride → 1-Benzyl-1H-imidazol-2-ylamine

HRID 388986Notes

Reaction equation

HRID 388986 reaction equation
[CH2:1]([N:8]1[CH:12]=[CH:11][N:10]=[C:9]1[N+:13]([O-])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[NH4+]>[Fe]>[CH2:1]([N:8]1[CH:12]=[CH:11][N:10]=[C:9]1[NH2:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 25517Ammonium ChlorideHCID 3311201-benzyl-2-nitro-1H-imidazole

Product 1

HCID 426145331-Benzyl-1H-imidazol-2-ylamine

Reagents, catalysts & solvents 1

HCID 23925IronCatalyst

Procedure

The nitroimidazole (1.5 mmol) from above reduced using iron powder and ammonium chloride employing the procedure described in Example 159 to yield 1-benzyl-2-amino-1H-imidazole which was used without any purification.

Sources & evidence

ORD record
ord-95c64cb8c30a4af5baea32bd8db998f5
Source dataset
uspto-grants-2013_02
Patent number
US08377983B2

Reaction notes

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