Hydrochloric Acid → HCID 178521767, compound

HRID 388988Notes

Reaction equation

HRID 388988 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:33]([C:34](=[O:45])[NH:35][C:36]3[CH:44]=[C:43]4[C:39]([CH:40]=[N:41][NH:42]4)=[CH:38][CH:37]=3)=[CH:32][C:17]3[N:18]=[C:19]([NH:21][C:22]4[N:23]([CH:27]5[CH2:31][CH2:30][CH2:29][CH2:28]5)[CH:24]=[CH:25][N:26]=4)[NH:20][C:16]=3[CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[NH:42]1[C:43]2[C:39](=[CH:38][CH:37]=[C:36]([NH:35][C:34]([C:33]3[C:14]([N:11]4[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]4)=[CH:15][C:16]4[NH:20][C:19]([NH:21][C:22]5[N:23]([CH:27]6[CH2:28][CH2:29][CH2:30][CH2:31]6)[CH:24]=[CH:25][N:26]=5)=[N:18][C:17]=4[CH:32]=3)=[O:45])[CH:44]=2)[CH:40]=[N:41]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178452216HCID 178452216, compound

Product 1

HCID 178521767HCID 178521767, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product from Example 182 was treated with 4M HCl in dioxane employing the procedure described for Example 156 to afford 2-(1-cyclopentyl-1H-imidazol-2-ylamino)-6-piperazin-1-yl-1H-benzoimidazole-5-carboxylic acid (1H-indazol-6-yl)amide as a hydrochloride salt. MS: m/z 511 (M+H)+.

Sources & evidence

ORD record
ord-ed8dbd13d44244b1a7c241ae4cbf9875
Source dataset
uspto-grants-2013_02
Patent number
US08377983B2

Reaction notes

Loading…