HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 389029Generated: October 31, 2026
Trifluoroacetic anhydride → (4-Oxo-4,10-dihydro-9-oxa-3-thiabenzo[f]azulen-6-ylsulfanyl)acetic acid
https://huagongshe.com/reaction/389029
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic anhydride | HCID 9845 | — |
| Reactant | 3-(4-Carboxymethylsulfanylphenoxymethyl)thiophene-2-carboxylic acid | HCID 68486463 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | (4-Oxo-4,10-dihydro-9-oxa-3-thiabenzo[f]azulen-6-ylsulfanyl)acetic acid | HCID 68488427 | 98% |
Reaction Steps
Trifluoroacetic acid anhydride (28.0 mL, 201 mmol) was added to a dichloroethane (300 mL) solution of the compound obtained in Example 20 (29.0 g, 89 mmol), and the mixture was stirred overnight at 60° C. The solvents were distilled off under a reduced pressure, and water was added to the residue. The precipitated crystals were separated by filtration and dried, to give 26.7 g (98%) of the captioned compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08377967B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-e6226f7b1b3f418fa429d6c102a15a4c |
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| Source note | uspto-grants-2013_02 |
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