反应详情

温度

62 °C

Piperazine (20.0 g, 232 mmol) and 3,6-dichloropyridazine (34.6 g, 232 mmol) were mixed with 2-butanone and heated at 62° C. for 16 h. The reaction mixture was cooled to room temperature and the precipitated product filtered and washed with 2-butanone. The solid was redissolved in DCM (250 mL), filtered and the filtrate evaporated. The solid was dried in vacuo to yield 37.3 g, 81% 3-chloro-6-piperazin-1-ylpyridazine.

1. temperatureThe reaction mixture was cooled to room temperature
2. filtrationthe precipitated product filtered
3. washwashed with 2-butanone
4. dissolutionThe solid was redissolved in DCM (250 mL)
5. filtrationfiltered
6. customthe filtrate evaporated
7. customThe solid was dried in vacuo