Hydrochloric Acid → HCID 44469456, compound

HRID 38907Notes

Reaction equation

HRID 38907 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[O:18][C:17]3[CH:19]=[C:20]([S:23]([CH3:26])(=[O:25])=[O:24])[CH:21]=[CH:22][C:16]=3[O:15][CH2:14]2)(=O)=O)=CC=1.[CH3:27][NH:28][CH2:29][CH2:30][CH3:31].Cl>C(#N)C>[CH3:27][N:28]([CH2:12][CH:13]1[O:18][C:17]2[CH:19]=[C:20]([S:23]([CH3:26])(=[O:24])=[O:25])[CH:21]=[CH:22][C:16]=2[O:15][CH2:14]1)[CH2:29][CH2:30][CH3:31]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 12315N-MethylpropylamineHCID 86652933[7-(Methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate

Product 1

HCID 44469456HCID 44469456, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 14 using [7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate (0.175 g, 0.44 mmol), N-methylpropan-1-amine (0.35 ml) and ACN (2 ml). Yield: 0.11 g, 84%. The amine was converted to the hydrochloric acid salt and crystallized from MeOH/Et2O. M.p. 222° C. MS m/z (rel. intensity, 70 eV) 299 (M+, 1) 86 (100), 58 (8), 84 (6), 87 (6).

Workup

  1. customPreparation
  2. customcrystallized from MeOH/Et2O

Sources & evidence

ORD record
ord-e5d68752d7a84729b8c2cade31d79ddc
Source dataset
uspto-grants-2013_09
Patent number
US08524766B2

Reaction notes

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